Dandelion root extract (DRE) has shown promising anti-cancer properties, particularly in colon cancer cells. Here’s what the research suggests:
– Colon Cancer Treatment: DRE can induce apoptosis, or programmed cell death, in over 95% of colon cancer cells within 48 hours, while leaving healthy cells intact. In lab tests, DRE slowed tumor growth by over 90% in mice with human colon tumors.
– Mechanism of Action: DRE disrupts mitochondrial membrane potential and increases Reactive Oxygen Species (ROS) levels in cancer cells’ mitochondria, ultimately killing them. It also affects specific signaling pathways involved in cancer cell proliferation and survival.
– Potential Applications: Researchers believe DRE could be a safe, multi-targeted cancer therapy due to its ability to activate multiple cell death pathways and inhibit cancer cell migration.
– Clinical Trials: While promising, further clinical trials are needed to validate these results in humans. In fact, a Phase I human trial is underway in Canada to determine the safety and tolerability of DRE in treating terminal cancer patients .
Some notable findings on DRE’s effects on various cancers include :
– Leukemia: DRE has been shown to kill leukemia cells while sparing healthy cells.
– Melanoma: DRE induces apoptosis in chemo-resistant melanoma skin cancer cells without toxicity to healthy cells.
– Breast Cancer: DRE affects PI3/AKT signaling pathways, inhibiting the expression of choline kinase alpha (CHKA).
To incorporate DRE into your health regimen, consider the following :
– Dosage: Consult a doctor before using DRE, especially if you’re taking other medications.
– Preparation: DRE can be consumed as a tea, tincture, or capsule. You can also harvest your own dandelion roots and dry them to make a powder or tea.
– Precautions: Some people may experience allergic reactions or heartburn. If you have gallbladder problems or gallstones, consult a doctor before using DRE.